Evaluation of an ion source with a tubular nebulizer for microflow atmospheric pressure chemical ionization

0490859 - ÚOCHB 2019 RIV AT eng J - Článek v odborném periodiku
Strmeň, Timotej - Vrkoslav, Vladimír - Pačes, Ondřej - Cvačka, Josef
Evaluation of an ion source with a tubular nebulizer for microflow atmospheric pressure chemical ionization.
Monatshefte fur Chemie. Roč. 149, č. 6 (2018), s. 987-994. ISSN 0026-9247. E-ISSN 1434-4475
Grant CEP: GA ČR(CZ) GA16-01639S
Institucionální podpora: RVO:61388963
Klíčová slova: charge transfer * hydrogen transfer * mass spectroscopy * micro-APCI * tubular nebulizer
Obor OECD: Analytical chemistry
Impakt faktor: 1.501, rok: 2018

An atmospheric pressure chemical ionization (APCI) source designed for microliter-per-minute flow rates (0.5-10.0 mm(3)/min) was constructed. A simple resistively heated 1/8 in. OD tube-based nebulizer, together with a corona-discharge electrode was positioned in front of the entrance capillary of a mass spectrometer. Working parameters of the ion source were optimized, and its performance was evaluated. The limit of detection for directly infused acridine was found to be lower for micro-APCI (10 fmol/s) than for conventional APCI (170 fmol/s), and the linear dynamic range was significantly wider for the micro-APCI source. The micro-APCI and conventional APCI sources provided similar, but not identical mass spectra. The micro-APCI source was used as a detector for high-performance liquid chromatography at 10 mm(3)/min, the limit of detection for acridine was 690 fmol, which was about ten times lower value than in conventional HPLC.
Trvalý link: http://hdl.handle.net/11104/0284992