Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals

0490250 - FZÚ 2019 RIV GB eng J - Článek v odborném periodiku
Villa, I. - Villa, Ch. - Monguzzi, A. - Babin, Vladimir - Tervoort, E. - Nikl, Martin - Niederberger, M. - Torrente, Y. - Vedda, A. - Lauria, A.
Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals.
Nanoscale. Roč. 10, č. 17 (2018), s. 7933-7940. ISSN 2040-3364. E-ISSN 2040-3372
GRANT EU: European Commission(XE) 690599 - ASCIMAT
Institucionální podpora: RVO:68378271
Klíčová slova: cellular imaging * luminescence
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 6.970, rok: 2018

Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu3+-doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for cellular optical imaging and as radiosensitive materials for clinical treatment. Furthermore, viability and biocompatibility tests on artificially stressed cell cultures reveal their ability to buffer reactive oxygen species, proposing an anti-cytotoxic feature interesting for biomedical applications.
Trvalý link: http://hdl.handle.net/11104/0284513