Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration

0489769 - ÚOCHB 2019 RIV US eng J - Článek v odborném periodiku
Park, K. - Kuo, Y. - Shvadchak, Volodymyr - Ingargiola, A. - Dai, X. - Hsiung, L. - Kim, W. - Zhou, H. - Zou, P. - Levine, A. J. - Li, J. - Weiss, S.
Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration.
Science Advances. Roč. 4, č. 1 (2018), č. článku e1601453. ISSN 2375-2548. E-ISSN 2375-2548
Institucionální podpora: RVO:61388963
Klíčová slova: membrane potential * nanoparticles * sensors
Obor OECD: Biophysics
Impakt faktor: 12.804, rok: 2018
http://advances.sciencemag.org/content/4/1/e1601453.full

We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.
Trvalý link: http://hdl.handle.net/11104/0284133