Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster

0489356 - BC 2019 RIV GB eng J - Článek v odborném periodiku
Ibrahim, Emad - Dobeš, P. - Kunc, M. - Hyršl, P. - Kodrík, Dalibor
Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster.
Journal of Insect Physiology. Roč. 107, MAY 31 (2018), s. 167-174. ISSN 0022-1910. E-ISSN 1879-1611
Grant CEP: GA ČR(CZ) GA17-03253S
Institucionální podpora: RVO:60077344
Klíčová slova: adipokinetic hormone * adenosine * Drosophila
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.862, rok: 2018
https://www.sciencedirect.com/science/article/pii/S0022191018300787

This study examined how adipokinetic hormone (AKH) and adenosine affect defense responses in Drosophila larvae infected with entomopathogenic nematodes (EPN). Three loss-of-function mutant larvae were tested: Akh1, AdoR1 (adenosine receptor), and Akh1 AdoR1. Mortality decreased in all mutants post-EPN infection compared with the control (w1118), and co-application of AKH with EPN significantly enhanced this trend. This was accompanied by elevating carbon dioxide production, a measure of metabolism. Infection elevated haemolymph lipid and carbohydrate content, but dropped level of protein after EPN infection. Furthermore, AKH application in w1118 larvae significantly increased movement distance and percentage of larval activity, but reduced velocity.
Trvalý link: http://hdl.handle.net/11104/0285086