Počet záznamů: 1  

The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy

  1. 1.
    0489335 - FGÚ 2019 RIV CH eng J - Článek v odborném periodiku
    Janča, R. - Kršek, P. - Ježdík, P. - Čmejla, R. - Tomášek, M. - Komárek, V. - Marusič, P. - Jiruška, Přemysl
    The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy.
    Frontiers in Neurology. Roč. 9, Mar 23 (2018), č. článku 184. ISSN 1664-2295. E-ISSN 1664-2295
    Grant CEP: GA MZd(CZ) NV15-29835A
    Institucionální podpora: RVO:67985823
    Klíčová slova: interictal epileptiform discharges * brain networks * epilepsy surgery * irritative zone * propagation * neocortical epilepsy
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 2.635, rok: 2018

    Between seizures, irritative network generates frequent brief synchronous activity, which manifests on the EEG as interictal epileptiform discharges (IEDs). Recent insights into the mechanism of IEDs at the microscopic level have demonstrated a high variance in the recruitment of neuronal populations generating IEDs and a high variability in the trajectories through which IEDs propagate across the brain. These phenomena represent one of the major constraints for precise characterization of network organization and for the utilization of IEDs during presurgical evaluations. We have developed a new approach to dissect human neocortical irritative networks and quantify their properties. We have demonstrated that irritative network has modular nature and it is composed of multiple the extent of IED activity generated. The global activity of the irritative network is determined by long-term and circadian fluctuations in sub-region spatiotemporal properties. Also, the most active sub-region co-localizes with the seizure onset zone in 12/14 cases. This study demonstrates that principles of recruitment variability and propagation are conserved at the macroscopic level and that they determine irritative network properties in humans. Functional stratification of the irritative network increases the diagnostic yield of intracranial investigations with the potential to improve the outcomes of surgical treatment of neocortical epilepsy.
    Trvalý link: http://hdl.handle.net/11104/0283774

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.