Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei

0488335 - BC 2018 RIV CZ eng O - Ostatní výsledky
Zíková, Alena - Panicucci, Brian - Gahura, Ondřej
Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei.
2017
Grant CEP: GA MŠMT LL1205
Institucionální podpora: RVO:60077344
Klíčová slova: IF1 * ATP synthase * T. brucei
Obor OECD: Biochemistry and molecular biology

During hypoxia aerobic eukaryotes protect themselves against deleterious ATP depletion caused by the reversal of mitochondrial (mt) ATP synthase activity to ATP hydrolysis, which is inevitable consequence of the mt membrane potential (m) collapse in the lack of oxygen. The protection involves IF1, a protein inhibiting ATP hydrolysis by reversible binding to F1-ATPase, the catalytic sector of the enzyme.

Trvalý link: http://hdl.handle.net/11104/0282921