Porous heat-treated polyacrylonitrile scaffolds for bone tissue engineering

0488299 - ÚMCH 2019 RIV US eng J - Článek v odborném periodiku
Vetrík, Miroslav - Pařízek, Martin - Hadraba, Daniel - Kukačková, Olivia - Brus, Jiří - Hlídková, Helena - Kománková, Lucie - Hodan, Jiří - Sedláček, Ondřej - Šlouf, Miroslav - Bačáková, Lucie - Hrubý, Martin
Porous heat-treated polyacrylonitrile scaffolds for bone tissue engineering.
ACS Applied Materials and Interfaces. Roč. 10, č. 10 (2018), s. 8496-8506. ISSN 1944-8244. E-ISSN 1944-8252
Grant CEP: GA MZd(CZ) NV15-32497A; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NV16-30544A; GA ČR(CZ) GA16-03156S
Institucionální podpora: RVO:61389013 ; RVO:67985823
Klíčová slova: 3D scaffolds * black orlon * carbon-based material
Obor OECD: Polymer science; Biomaterials (as related to medical implants, devices, sensors) (FGU-C)
Impakt faktor: 8.456, rok: 2018

Heat-treated polyacrylonitrile (HT-PAN), also referred to as black orlon (BO), is a promising carbon-based material used for applications in tissue engineering and regenerative medicine. To the best of our knowledge, no such complex bone morphology-mimicking three-dimensional (3D) BO structure has been reported to date. We report that BO can be easily made into 3D cryogel scaffolds with porous structures, using succinonitrile as a porogen. The cryogels possess a porous morphology, similar to bone tissue. The prepared scaffolds showed strong osteoconductive activity, providing excellent support for the adhesion, proliferation, and mitochondrial activity of human bone-derived cells. This effect was more apparent in scaffolds prepared from a matrix with a higher content of PAN (i.e., 10% rather than 5%). The scaffolds with 10% of PAN also showed enhanced mechanical properties, as revealed by higher compressive modulus and higher compressive strength. Therefore, these scaffolds have a robust potential for use in bone tissue engineering.
Trvalý link: http://hdl.handle.net/11104/0283288