G-Protein-Coupled Receptor Dimers

0487911 - ÚMG 2018 RIV CH eng M - Část monografie knihy
Blahoš, Jaroslav
Metabotropic Glutamate Receptors.
G-Protein-Coupled Receptor Dimers. Cham: Springer Nature, 2017 - (Di Giovanni, G.), s. 327-357. ISBN 978-3-319-60172-4
Grant CEP: GA ČR GAP303/12/2408
Institucionální podpora: RVO:68378050
Klíčová slova: dimerization * GPCR * metabotropic glutamate receptors
Obor OECD: Neurosciences (including psychophysiology

Metabotropic Glutamate receptors (mGluRs) belong to Family C GPCRs.The mGluRs are putative dimers, both homodimers and, as revealed recently, also heterodimers. The heterodimerization may occur between different receptors (e.g. mGluR1/5, mGluR2/3), but also between splice variants resulting from alternative transcription of one gene (mGluR1a/b). This leads to previously unexpected diversity both physiologically, and potentially pharmacologically.
Trvalý link: http://hdl.handle.net/11104/0282517