Cajal bodies and snRNPs friends with benefits

0487053 - ÚMG 2018 RIV US eng J - Článek v odborném periodiku
Staněk, David
Cajal bodies and snRNPs friends with benefits.
RNA biology. Roč. 14, č. 6 (2017), s. 671-679. ISSN 1547-6286. E-ISSN 1555-8584
Grant CEP: GA ČR GA15-00790S
Institucionální podpora: RVO:68378050
Klíčová slova: spinal muscular-atrophy * small nuclear-rna * u4/u6.u5 tri-snrnp * xenopus-laevis oocytes * u6 spliceosomal rna * coiled bodies * smn complex * u1 snrnp * u2 snrnp * in-vivo
Obor OECD: Cell biology
Impakt faktor: 5.216, rok: 2017

Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal bodies. I also evaluate the contribution of the Cajal body in snRNP quality control and discuss the role of snRNPs in Cajal body formation.
Trvalý link: http://hdl.handle.net/11104/0281743