Iterative photoinduced chain functionalization as a generic platform for advanced polymeric drug delivery systems

0486793 - ÚMCH 2019 RIV DE eng J - Článek v odborném periodiku
Al Samad, A. - Bethry, A. - Janoušková, Olga - Ciccione, J. - Wenk, C. - Coll, J.-L. - Subra, G. - Etrych, Tomáš - El Omar, F. - Bakkour, Y. - Coudane, J. - Nottelet, B.
Iterative photoinduced chain functionalization as a generic platform for advanced polymeric drug delivery systems.
Macromolecular Rapid Communications. Roč. 39, č. 3 (2018), s. 1-5, č. článku 1700502. ISSN 1022-1336. E-ISSN 1521-3927
Grant CEP: GA MŠMT(CZ) LO1507; GA MŠMT(CZ) LQ1604
Institucionální podpora: RVO:61389013
Klíčová slova: drug delivery systems * functionalization of polymers * photochemistry
Obor OECD: Polymer science
Impakt faktor: 4.078, rok: 2018

Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(.epsilon.-caprolactone) (PCL) platform via an efficient thiol–yne photoaddition. Fine-tuning over the design is achieved, as illustrated with targeting and enzyme-responsive DDS.
Trvalý link: http://hdl.handle.net/11104/0282582