Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

0486290 - ÚMG 2018 RIV GB eng J - Článek v odborném periodiku
Gbelcová, H. - Rimpelová, S. - Knejzlík, Z. - Šáchová, Jana - Kolář, Michal - Strnad, Hynek - Repiska, V. - D'Acunto, C.W. - Ruml, T. - Vítek, L.
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
Lipids in Health and Disease. Roč. 16, zima (2017), č. článku 250. E-ISSN 1476-511X
Grant CEP: GA MZd(CZ) NT13112
Institucionální podpora: RVO:68378050
Klíčová slova: Farmesyl pyrophosphate * Gene expression * Geranylgeranyl pyrophosphate * HMG-CoA reductase inhibitors * Isoprenoids * K-Ras oncogene * Mevalonate * Pncreatic cancer * Prenylation * Statins
Obor OECD: Cell biology
Impakt faktor: 2.663, rok: 2017

Background: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in pancreatic cancer. In our study, we evaluated the effect of three key intermediates of the mevalonate pathway on GFP-K-Ras protein localization and the gene expression profile in pancreatic cancer cells after exposure to individual statins.
Trvalý link: http://hdl.handle.net/11104/0281151