Počet záznamů: 1
Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages
- 1.0485878 - FGÚ 2018 RIV US eng J - Článek v odborném periodiku
Rombaldová, Martina - Janovská, Petra - Kopecký, Jan - Kuda, Ondřej
Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages.
Biochemical and Biophysical Research Communications. Roč. 490, č. 3 (2017), s. 1080-1085. ISSN 0006-291X. E-ISSN 1090-2104
Grant CEP: GA ČR(CZ) GA16-05151S; GA MŠMT(CZ) LTAUSA17173
Institucionální podpora: RVO:67985823
Klíčová slova: adipose tissue * macrophages * omega-3 PUFA * fatty acid re-esterification * lipolysis * lipid mediators
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 2.559, rok: 2017
It is becoming increasingly apparent that mutual interactions between adipocytes and immune cells are key to the integrated control of adipose tissue inflammation and lipid metabolism in obesity, but little is known about the non-inflammatory functions of adipose tissue macrophages (ATMs) and how they might be impacted by neighboring adipocytes. In the current study we used metabolipidomic analysis to examine the adaptations to lipid overload of M1 or M2 polarized macrophages co-incubated with adipocytes and explored potential benefits of omega-3 polyunsaturated fatty acids (PUFA). Macrophages adjust their metabolism to process excess lipids and M2 macrophages in turn modulate lipolysis and fatty acids (FA) re-esterification of adipocytes. While M1 macrophages tend to store surplus FA as triacylglycerols and cholesteryl esters in lipid droplets, M2 macrophages channel FA toward re-esterification and beta-oxidation. Dietary omega-3 PUFA enhance beta-oxidation in both M1 and M2. Our data document that ATMs contribute to lipid trafficking in adipose tissue and that omega-3 PUFA could modulate FA metabolism of ATMs.
Trvalý link: http://hdl.handle.net/11104/0280803
Počet záznamů: 1