Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities

0485728 - BFÚ 2018 RIV DE eng J - Článek v odborném periodiku
Hofmanová, Jiřina - Slavík, J. - Ovesná, P. - Tylichová, Zuzana - Vondráček, Jan - Straková, Nicol - Vaculová, Alena - Cigánek, M. - Kozubík, Alois - Knopfová, L. - Šmarda, J. - Machala, M.
Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities.
European Journal of Nutrition. Roč. 56, č. 4 (2017), s. 1493-1508. ISSN 1436-6207. E-ISSN 1436-6215
Grant CEP: GA ČR GA13-09766S; GA MZd(CZ) NV15-30585A
Institucionální podpora: RVO:68081707
Klíčová slova: docosahexaenoic acid * cancer-cells * epithelial-cells
Obor OECD: Oncology
Impakt faktor: 4.423, rok: 2017

Although beneficial effects of the dietary n-3 docosahexaenoic acid (DHA) or butyrate in colon carcinogenesis have been implicated, the mechanisms of their action are not fully clear. Here, we investigated modulations of composition of individual phospholipid (PL) classes, with a particular emphasis on cardiolipins (CLs), in colon cells treated with DHA, sodium butyrate (NaBt), or their combination (DHA/NaBt), and we evaluated possible associations between lipid changes and cell fate after fatty acid treatment.
Trvalý link: http://hdl.handle.net/11104/0280680