A novel, three-component reaction to the synthesis of 3-amino-4-cyano-5-aryl-1H-pyrrole-2-carboxamides

0485476 - FZÚ 2018 RIV GB eng J - Článek v odborném periodiku
Mohammadi, B. - Khorrami, B.R. - Ghorbani, M. - Dušek, Michal
A novel, three-component reaction to the synthesis of 3-amino-4-cyano-5-aryl-1H-pyrrole-2-carboxamides.
Tetrahedron. Roč. 73, č. 52 (2017), s. 7291-7294. ISSN 0040-4020. E-ISSN 1464-5416
Institucionální podpora: RVO:68378271
Klíčová slova: amidopyrrole * multi-component reaction * water * malononitrile * hydroxylamine hydrochloride
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 2.377, rok: 2017

This work described a novel and efficient synthesis of 3-amino-4-cyano-5-phenyl-1H-pyrrole-2-carboxamides. The synthesis was carried out via a simple three-component reaction between arylidenmalononitrile, malononitrile and hydroxylamine hydrochloride in solvent-free conditions. Short reaction times, good to excellent yields of products, inexpensive and readily available starting material, and time and energy saving are the main advantages of this method. The structures of the products were confirmed by 1HNMR, 13CNMR, IR and single crystal X-ray analysis.

Trvalý link: http://hdl.handle.net/11104/0280490