Tick-Borne Encephalitis (TBE)

0485360 - BC 2018 RIV SG eng M - Část monografie knihy
Růžek, Daniel - Yoshii, K. - Bloom, M.E. - Gould, E. A.
Virology.
Tick-Borne Encephalitis (TBE). Singapore: Global Health Press Pte Ltd, 2017 - (Dobler, G.; Erber, W.; Schmitt, H.). ISBN 978-981-11-1903-3
Institucionální podpora: RVO:60077344
Klíčová slova: Flavivirus * RNA molecule * proteins
Obor OECD: Virology

TBEV is the most medically important member of the tick-borne serocomplex group within the genus Flavivirus, family Flaviviridae.
Three antigenic subtypes of TBEV correspond to the 3 recognized genotypes: Western, also known as European, Far Eastern, and Siberian. An additional 2 genotypes have been identified in the Irkutsk region of Russia.
TBEV virions are small enveloped spherical particles about 50 nm in diameter.
The TBEV genome consists of a single-stranded positive sense RNA molecule.
The genome encodes one open reading frame (ORF), which is flanked by untranslated (non-coding) regions (UTRs).
The 5′-UTR end has a methylated nucleotide cap for canonical cellular translation. The 3′-UTR is not polyadenylated and is characterized by extensive length and sequence heterogeneity.
The ORF encodes one large polyprotein, which is co- and post-translationally cleaved into 3 structural proteins (C, prM, and E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).
TBEV replicates in the cytoplasm of the host cell in close association with virus-induced intracellular membrane structures. Virus assembly occurs at the endoplasmic reticulum. The immature virions are transported to the Golgi complex, and mature virions pass through the host secretory pathway and are finally released from the host cell by fusion of the transport vesicle membrane with the plasma membrane.
Trvalý link: http://hdl.handle.net/11104/0280413