Arthropod Vector: Controller of Disease Transmission

0485348 - BC 2018 RIV GB eng M - Část monografie knihy
Shaw, D.K. - McClure, E. E. - Kotsyfakis, Michalis - Pedra, J. H. F.
Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin.
Arthropod Vector: Controller of Disease Transmission. UK: Elsevier, 2017, s. 169-194. ISBN 9780128053607
Institucionální podpora: RVO:60077344
Klíčová slova: inflammasome * innate immune signaling * nod-like receptors (NLRs) * pathogen effectors * tick saliva
Obor OECD: Biochemistry and molecular biology

Host immunity can be divided into two branches: innate and adaptive. The Toll-like and Nod-like receptor pathways are the two best characterized innate signaling cascades. Parasitic organisms have evolved a wide range of methods to invade and persist on and/or within hosts. The main crux of this life strategy hinges on the ability to evade or interrupt the host immune response. In the context of microbial pathogenesis, secreted effector molecules are an immunomodulatory staple. Similarly, ectoparasitic organisms, such as a tick, use salivary molecules to modulate immune processes that favor blood feeding and survival. In this chapter, we will discuss the commonalities between the immunomodulatory properties of tick saliva and microbial-derived effector molecules in the context of Nod-like receptor signaling. Given the extensive body of literature surrounding microbial effectors, we offer the opinion that this can be used to guide discovery and molecular characterization of tick salivary molecules.
Trvalý link: http://hdl.handle.net/11104/0280407