A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts

0485197 - BC 2018 RIV US eng J - Článek v odborném periodiku
Ishemgulova, A. - Kraeva, N. - Hlaváčová, J. - Zimmer, S.L. - Butenko, A. - Podešvová, L. - Leštinová, T. - Lukeš, Julius - Kostygov, A. - Votýpka, Jan - Volf, P. - Yurchenko, V.
A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts.
PLoS Neglected Tropical Diseases. Roč. 11, č. 7 (2017), č. článku e0005782. ISSN 1935-2735. E-ISSN 1935-2735
Grant CEP: GA MŠMT LL1601
Institucionální podpora: RVO:60077344
Klíčová slova: multiple sequence alignment * sand flies * trypanosoma-brucei * expression system * p-loop * transmission * evolution * parasites * resource * kinases
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.367, rok: 2017

Leishmania virulence factors responsible for the complicated epidemiology of the various leishmaniases remain mainly unidentified. This study is a characterization of a gene previously identified as upregulated in two of three overlapping datasets containing putative factors important for Leishmania's ability to establish mammalian intracellular infection and to colonize the gut of an insect vector.
Trvalý link: http://hdl.handle.net/11104/0280366