0485178 - ÚŽFG 2018 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Ellederová, Zdeňka - Baxa, Monika - Vidinská, Daniela - Bohuslavová, Božena - Vochozková, Petra - Šmatlíková, Petra - Klíma, Jiří - Valeková, Ivona - Ardan, Taras - Juhás, Štefan - Juhásová, Jana - Konvalinková, R. - Klempíř, J. - Pokorný, M. - Krupička, R. - Kauler, J. - Hansíková, H. - Motlík, Jan
Following the phenotype development of TgHD minipigs by invasive and noninvasive approach.
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 31-32.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: minipigs * Huntington´s disease
Obor OECD: Neurosciences (including psychophysiology

Recent promising treatments for Huntington’s disease (HD) may require pre-clinical testing in large animals. In 2009, we generated HD transgenic (TgHD) minipigs with one copy encoding the N-terminal part (548 aa) of human huntingtin (HTT) with 124 CAG/CAA repeats integrated into chromosome 1 q24-q25. The successful germ line transmission occurred through four successive generations.
Trvalý link: http://hdl.handle.net/11104/0280254