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Double strand DNA breaks response in Huntington´s disease
- 1.0485173 - ÚŽFG 2018 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Šolc, Petr
Double strand DNA breaks response in Huntington´s disease.
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 29-30.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: DNA damage response
Obor OECD: Human genetics
There are strong evidences that DNA damage response (DDR) signalling significantly underline the molecular pathology of polyglutamine (polyQ) diseases, including Huntington´s disease (HD) [1-4]. Double strand DNA breaks (DSBs) are the most deleterious DNA lesions.
In this talk I will review how DDR on DSBs is affected in HD.
Trvalý link: http://hdl.handle.net/11104/0280249
Počet záznamů: 1