Potent anti-spasticity and anti-nociceptive effect of subpial GAD65 and VGAT gene delivery in rat and mice

0485158 - ÚŽFG 2018 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Maršala, M. - Tadokoro, T. - Hernandez, M. B. - Navarro, M. - Maršala, S. - Miyanohara, A. - Juhás, Štefan - Juhásová, Jana - Platoshyn, O.
Potent anti-spasticity and anti-nociceptive effect of subpial GAD65 and VGAT gene delivery in rat and mice.
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 20-21.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: rat * mouse
Obor OECD: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

In previous studies we have developed a novel spinal subpial (SP) AAV delivery technique in adult mice, rats and minipigs. Using this technique we have demonstrated potent and wide-spread transgene (GFP) expression in spinal white and gray matter after a single SP bolus of AAV9-UBI-GFP.
Trvalý link: http://hdl.handle.net/11104/0280231