Helquat derivatives, preparation thereof, and use thereof as medicaments

0484671 - ÚOCHB 2018 RIV eng P - Patentový dokument
Teplý, Filip - Hájek, Miroslav
Helquat derivatives, preparation thereof, and use thereof as medicaments.
2017. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 22.02.2017. Číslo patentu: EP2945937
Institucionální podpora: RVO:61388963
Klíčová slova: helquat derivatives * cellular proliferation diseases * medicaments
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2945937B1&KC=B1&FT=D&ND=4&date=20170222&DB=&locale=en_EP#

The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl, up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula (II) or general formula (III) wherein R4 is substituted or unsubstituted aryl, T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
Trvalý link: http://hdl.handle.net/11104/0279839