Selected lactobacilli strains restore mouse post-natal growth dynamics and somatotropic axis aktivity upon undernutrition

0484645 - MBÚ 2018 JP A - Abstrakt
Schwarzer, Martin
Selected lactobacilli strains restore mouse post-natal growth dynamics and somatotropic axis aktivity upon undernutrition.
Development of intestinal microbiot and human diseases, Abstracts. Tokio: 26th Symposium on intestinal flora, 2017. s. 17-18.
[26th Symposium on intestinal flora. 17.10.2017, Tokio]
Institucionální podpora: RVO:61388971
Klíčová slova: Somatotropic axis * germ-free * Lactobacillus
Obor OECD: Physiology (including cytology)

The juvenile period is marked by the exponential gain in body weight and size. These two physical traits can manifest large phenotypic range based on the interaction between nutritional input and the organism’s hormonal cues. In mammals, post-natal growth is controlled by the activity of the somatotropic axis, in which Growth Hormone instructs liver and peripheral tissues to produce Insulin-like Growth Factor-1 (IGF-1), to promote organ and systemic growth. Malnutrition resulting from deficiencies in calorie or protein intake is generally called protein-energy malnutrition. In its acute form it leads to rapid weight loss or failure to gain weight normally. Contrary to the acute malnutrition, the chronic malnutrition is a result of inadequate nutrition over a long period of time. Chronic undernutrition alters the somatotropic axis activity by triggering a state of GH-resistance which leads to the failure of linear growth and, as a result, to short and thin individuals. Its causative factors are still poorly understood and until recently, nothing was known about the role of the microbiota in this condition in mammals. In juvenile mice we have shown that microbiota is necessary to sustains both weight gain and longitudinal growth upon normal- and under-nutrition. We found that the liver and peripheral tissues of germ-free (GF) mice bear hallmarks of reduced GH sensitivity indicating that the intestinal microbiota sustains somatotropic axis activity. Previously, using a gnotobiotic Drosophila model, Storelli et al. has shown that L. plantarum is able to promote juvenile growth upon protein scarcity in a strain dependent manner6. Upon monoassociation of GF mice we showed that strain of L. plantarum previously qualified for its growth promoting ability in the Drosophila system is sufficient to fully recapitulate the microbiota effect on growth and the somatotropic axis activity in mice.
Trvalý link: http://hdl.handle.net/11104/0279808