Polysaccharides isolated from Lactobacillus casei LOCK0919 probably promote benefits to the host.

0484606 - MBÚ 2018 NL eng A - Abstrakt
Hermanová, Petra - Schwarzer, Martin - Šrůtková, Dagmar - Kozáková, Hana - Cukrowska, B. - Górska, S. - Hudcovic, Tomáš
Polysaccharides isolated from Lactobacillus casei LOCK0919 probably promote benefits to the host.
Abstracts of lectures and posters The 6th Beneficial Microbes Conference. Amsterdam: Conference secretariat, 2017.
[6th Beneficial Microbes Conference, Pre-and Probiotics for lifelong human and animal health. 09.10.2017-11.10.2017, Amsterdam]
Grant CEP: GA ČR GA15-07268S
Institucionální podpora: RVO:61388971
Klíčová slova: Polysaccharides * probiotics * Lactobacillus casei LOCK0919 * immunomodulatory properties
Obor OECD: Immunology

Lactobacilli are currently the most frequently used bacteria in probiotic products. We recently demonstrated that mixture of Lactobacillus (L.) rhamnosus LOCK0900, L. rhamnosus LOCK0908 and L. casei LOCK0919 (L919) have synergistic effect in induction of anti-allergic and regulatory cytokines in human blood cell culture. We found that L. casei LOCK0919 is a dominant colonizer of mice gut. We observed that probably polysaccharides contribute to the host colonization which may promote some benefits of the host. L919 produce two different polysaccharides which have distinct immunomodulatory properties compared to the whole bacteria.
Trvalý link: http://hdl.handle.net/11104/0280215