Počet záznamů: 1
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis
- 1.0484423 - FGÚ 2018 RIV US eng J - Článek v odborném periodiku
Zhang, H. - Wang, D. - Li, M. - Plecitá-Hlavatá, Lydie - D'Alessandro, A. - Tauber, Jan - Riddle, S. - Kumar, S. - Flockton, A. - McKeon, B. A. - Frid, M. G. - Reisz, J. A. - Caruso, P. - El Kasmi, K. C. - Ježek, Petr - Morrell, N. W. - Hu, Ch.-J. - Stenmark, K. R.
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.
Circulation. Roč. 136, č. 25 (2017), s. 2468-2485. ISSN 0009-7322. E-ISSN 1524-4539
Grant CEP: GA MŠMT(CZ) LH11055; GA MŠMT(CZ) LH15071; GA ČR(CZ) GA16-04788S
Institucionální podpora: RVO:67985823
Klíčová slova: hypoxia * metabolism * mitochondria * pyruvate kinase * shikonin * splicing factors * TEEP-46
Obor OECD: Respiratory systems
Impakt faktor: 18.881, rok: 2017
We have uncovered regulatory pathway responsible for metabolic changes in human and bovine hypertensive pulmonary arterial walls leading to hyperproliferation, apoptosis-resistance and proinflammation.
Trvalý link: http://hdl.handle.net/11104/0279597
Počet záznamů: 1