Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism

0484400 - ÚJF 2018 IE eng A - Abstrakt
Trnovská, J. - Pravenec, Michal - Šilhavý, Jan - Strnad, Hynek - Eigner, Sebastian - Eigner-Henke, Kateřina - Škop, V. - Malinská, Hana - Kazdová, L. - Drahota, Zdeněk
Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism.
Atherosclerosis. Elsevier. Roč. 263, č. 8 (2017), s. 71-71. ISSN 0021-9150. E-ISSN 1879-1484.
[85th Congress of the European-Atherosclerosis-Society (EAS). 23.04.2017-26.04.2017, Prague]
Grant CEP: GA ČR(CZ) GA13-04420S
Institucionální podpora: RVO:67985823 ; RVO:68081707 ; RVO:61389005 ; RVO:68378050
Klíčová slova: Brown Adipose Tissue (BAT) * Spontaneously Hypertensive Rat (SHR)
Kód oboru RIV: FR - Farmakologie a lékárnická chemie; CE - Biochemie (FGU-C); BO - Biofyzika (BFU-R); EB - Genetika a molekulární biologie (UMG-J)

In SHR-Retn strain we observed lower relative weight of interscapular BAT (-22%; P<0.05). Expression of the mouse transgenic resistin was associated with a significantly reduced oxidation of both palmitate (-34%, P<0.007) and glucose (-40%, P<0.001) in isolated BAT. SHR-Retn transgenic rats versus SHR controls exhibited a substantially reduced incorporation of palmitate (-23%, P<0.01) but not glucose into BAT lipids. In addition, in vivo microPET imaging revealed significantly reduced 18FFDG uptake in BAT induced by exposure to cold in SHR-Retn versus control SHR (-31%, P<0.05).
Trvalý link: http://hdl.handle.net/11104/0279562