Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

0483977 - ÚOCHB 2018 RIV CH eng B - Monografie kniha jako celek
Ježek, Jan - Hlaváček, Jan - Šebestík, Jaroslav
Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases.
Cham: Springer, 2017. 237 s. Progress in Drug Research, 72. ISBN 978-3-319-63952-9. ISSN 0071-786X
Grant CEP: GA ČR(CZ) GA14-00431S; GA ČR(CZ) GA17-00121S
Institucionální podpora: RVO:61388963
Klíčová slova: acridine * acridine-protein interactions * acridine-nucleic acid interactions * neurodegenerative diseases
Obor OECD: Organic chemistry

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis,
comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Trvalý link: http://hdl.handle.net/11104/0279147