Počet záznamů: 1  

Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model

  1. 1.
    0483483 - ÚMCH 2018 RIV DE eng J - Článek v odborném periodiku
    Kostiv, Uliana - Patsula, Vitalii - Noculak, A. - Podhorodecki, A. - Větvička, D. - Poučková, P. - Sedláková, Zdeňka - Horák, Daniel
    Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model.
    ChemMedChem. Roč. 12, Issue 24 (2017), s. 2066-2073. ISSN 1860-7179. E-ISSN 1860-7187
    Grant CEP: GA ČR(CZ) GA15-01897S
    Institucionální podpora: RVO:61389013
    Klíčová slova: upconversion nanospheres * phthalocyanine * photodynamic therapy
    Obor OECD: Polymer science
    Impakt faktor: 3.009, rok: 2017

    Photodynamic therapy (PDT) has garnered immense attention as a minimally invasive clinical treatment modality for malignant cancers. However, its low penetration depth and photodamage of living tissues by UV and visible light, which activate a photosensitizer, limit the application of PDT. In this study, monodisperse NaYF4:Yb3+/Er3+ nanospheres 20 nm in diameter, that serve as near-infrared (NIR)-to-visible light converters and activators of a photosensitizer, were synthesized by high-temperature co-precipitation of lanthanide chlorides in a high-boiling organic solvent (octadec-1-ene). The results demonstrate that the NaYF4:Yb3+/Er3+@SiO2-PEI-Pc-PEG nanospheres have great potential as a novel NIR-triggered PDT nanoplatform for deep-tissue cancer therapy.
    Trvalý link: http://hdl.handle.net/11104/0279476

     
     
Počet záznamů: 1  

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