Enzymology at the Membrane Interface: Intramembrane Proteases

0483415 - ÚOCHB 2018 RIV US eng M - Část monografie knihy
Stříšovský, Kvido
Mechanism and Inhibition of Rhomboid Proteases.
Enzymology at the Membrane Interface: Intramembrane Proteases. Cambridge: Academic Press, 2017 - (Gelb, M.), s. 279-293. Methods in Enzymology, 584. ISBN 978-0-12-812213-6
Grant CEP: GA MŠMT(CZ) LK11206; GA MŠMT LO1302
GRANT EU: European Commission(XE) 304154 - Rhomboid substrates
Grant ostatní: EMBO(DE) 2329
Institucionální podpora: RVO:61388963
Klíčová slova: rhomboid protease * mechanism * substrate specificity * inhibitor * disease
Obor OECD: Biochemistry and molecular biology

Intramembrane serine proteases of the rhomboid family are widespread, and their gradually uncovered functions in different organisms already suggest medical relevance for infectious diseases and cancer. However, selective inhibitors that could serve as research tools for rhomboids, for validation of their disease relevance, or as templates for drug development are lacking. Here I summarize the current knowledge about rhomboid protease mechanism and specificity, overview the currently used inhibitors, and conclude by proposing avenues for future development of rhomboid protease inhibitors.
Trvalý link: http://hdl.handle.net/11104/0278742