Chiral separation of novel diazenes on a polysaccharide-basedstationary phase in the reversed-phase mode

0483337 - FZÚ 2018 RIV DE eng J - Článek v odborném periodiku
Vojtylová, Terézia - Hamplová, Věra - Galewski, Z. - Korbecka, I. - Sýkora, D.
Chiral separation of novel diazenes on a polysaccharide-basedstationary phase in the reversed-phase mode.
Journal of Separation Science. Roč. 40, č. 7 (2017), s. 1465-1469. ISSN 1615-9306. E-ISSN 1615-9314
Grant CEP: GA ČR GA15-02843S
Grant ostatní: EU - ICT(XE) COST Action IC1208
Institucionální podpora: RVO:68378271
Klíčová slova: azobenzene * chiral separation * high-performance liquid chromatography * liquid-crystalline materials * photo-induced isomerization
Obor OECD: Analytical chemistry
Impakt faktor: 2.415, rok: 2017

Chiral HPLC separation of two recently synthesized liquid crystalline materials C1 and C2 was studied in the reversed-phase mode. Both materials have an azo-moiety and one chiral center in their molecular structures. The compounds were analyzed in both of their possible forms, the more thermodynamically stable E form and the labile Z form. The conditions and time scale of the UV-induced E toZ transition were briefly evaluated. Under the optimized conditions, we were able to baseline separate S and R enantiomers of both of the studied materials not only in their E forms, but also in their Z forms. In comparison to the separation in the normal-phase mode, which we have reported recently, the resolution in the reversed-phase mode is significantly better. Interestingly, peak reversal was noticed for the S and R enantiomers when the separation was carried out with E versus Z forms of both compounds.

Trvalý link: http://hdl.handle.net/11104/0278688