The release kinetics, antimicrobial activity and cytocompatibility of differently prepared collagen/hydroxyapatite/vancomycin layers: Microstructure vs. nanostructure

0482164 - ÚSMH 2018 RIV NL eng J - Článek v odborném periodiku
Suchý, Tomáš - Šupová, Monika - Klapková, E. - Adámková, V. - Závora, J. - Žaloudková, Margit - Rýglová, Šárka - Ballay, R. - Denk, František - Pokorný, M. - Sauerová, P. - Hubálek Kalbáčová, M. - Horný, L. - Veselý, J. - Voňavková, T. - Průša, R.
The release kinetics, antimicrobial activity and cytocompatibility of differently prepared collagen/hydroxyapatite/vancomycin layers: Microstructure vs. nanostructure.
European Journal of Pharmaceutical Sciences. Roč. 100, MAR 30 (2017), s. 219-229. ISSN 0928-0987. E-ISSN 1879-0720
Grant CEP: GA TA ČR(CZ) TA04010330
Institucionální podpora: RVO:67985891
Klíčová slova: coating * controlled release * drug delivery system * nanoparticle * pharmacokinetics * polymeric drug delivery system
Obor OECD: Biomaterials (as related to medical implants, devices, sensors)
Impakt faktor: 3.466, rok: 2017

Osteo-inductive resorbable collagen/hydroxyapatite layers allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface were developed. An evaluation was performed of the vancomycin release kinetics, antimicrobial efficiency and cytocompatibility. The results suggest that nano-structured collagen-hydroxyapatite layers impregnated with vancomycin following cross-linking provide suitable candidates for use as local drug delivery carriers.
Trvalý link: http://hdl.handle.net/11104/0277560