The deposition of inhaled manganese nanoparticles in mice organs

0481652 - ÚIACH 2018 IE eng A - Abstrakt
Machala, M. - Kulich, P. - Šerý, Omar - Dočekal, Bohumil - Večeřa, Zbyněk - Zeman, T. - Míšek, Ivan
The deposition of inhaled manganese nanoparticles in mice organs.
Toxicology Letters. Elsevier. Roč. 238, č. 2 (2015), s. 206-206. ISSN 0378-4274. E-ISSN 1879-3169.
[Congress of the European Societies of Toxicology (EUROTOX) /51./. 13.09.2015-16.09.2015, Porto]
Grant CEP: GA ČR(CZ) GBP503/12/G147
Institucionální podpora: RVO:68081715 ; RVO:67985904
Klíčová slova: nanoparticles * manganese oxide * inhalation chamber * mice
Kód oboru RIV: CB - Analytická chemie, separace

Biokinetics of manganese oxide (MnO·Mn2O3) nanoparticles (NPs) was studied in male ICR mice after 17-week exposure in inhalation chamber by transmission electron microscopy (TEM), scan electron microscopy (SEM) and electrothermal atomic absorption spectrometry (ET-AAS) analyses. The study focused on the distribution of Mn NPs in selected tissues (lung, erythrocytes, liver, spleen, brain). First, uniformity, shape and size of NPs, used for exposure inhalation experiments, were characterized by TEM. The NP size was on average 20nm (9–35 nm), and they mostly polygonal shape.
Trvalý link: http://hdl.handle.net/11104/0277177