0481583 - ÚPT 2018 RIV HR eng C - Conference Paper (international conference)
Vaškovicová, Naděžda - Skoupý, Radim - Hrubanová, Kamila - Kulich, P. - Turánek, J. - Krzyžánek, Vladislav
Localization of nanodiamonds inside cancer cells using cathodoluminescence imaging in the cryo-SEM.
13th Multinational Congress on Microscopy: Book of Abstracts. Zagreb: Ruder Bošković Institute, Croatian Microscopy Society, 2017 - (Gajović, A.; Weber, I.; Kovačević, G.; Čadež, V.; Šegota, S.; Peharec Štefanić, P.; Vidoš, A.), s. 80-81. ISBN 978-953-7941-19-2.
[Multinational Congress on Microscopy /13./. Rovinj (HR), 24.09.2017-29.09.2017]
R&D Projects: GA ČR(CZ) GA17-15451S; GA MŠMT(CZ) LO1212
Institutional support: RVO:68081731
Keywords : cryo-SEM * cathodoluminescence * nanodiamonds * cancer cells * THP1 cells
OECD category: Electrical and electronic engineering

Synthetic nanodiamonds, usually prepared with a method based on detonation, are carbon minerals with the size ranging between 5 and 200 nm. The detonation method is performed by an oxygen-deficient explosive mixture of TNT/RDX (trinitrotoluene / hexogene) that is allowed to detonate in a closed chamber. Nanodiamonds are neither biologically resorbable, nor degradable, however, certain biocompatible drugs may be present on their surface, functioning as cancer markers or a drug delivery system. The effect of cathodoluminescence (CL) present on nanodiamonds can be visualized with the use of an electron microscope.
Permanent Link: http://hdl.handle.net/11104/0277125