A simple neridronate-based surface coating strategy for upconversion nanoparticles: highly colloidally stable 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles for multimodal in vivo tissue imaging

0481234 - ÚMCH 2018 RIV GB eng J - Článek v odborném periodiku
Kostiv, Uliana - Lobaz, Volodymyr - Kučka, Jan - Švec, Pavel - Sedláček, Ondřej - Hrubý, Martin - Janoušková, Olga - Francová, P. - Kolářová, V. - Šefc, L. - Horák, Daniel
A simple neridronate-based surface coating strategy for upconversion nanoparticles: highly colloidally stable 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles for multimodal in vivo tissue imaging.
Nanoscale. Roč. 9, č. 43 (2017), s. 16680-16688. ISSN 2040-3364. E-ISSN 2040-3372
Grant CEP: GA ČR(CZ) GA15-01897S; GA MZd(CZ) NV16-30544A
Institucionální podpora: RVO:61389013
Klíčová slova: upconversion nanoparticles * PEG-neridronate * 125I radiolabeling
Obor OECD: Polymer science
Impakt faktor: 7.233, rok: 2017

In this report, monodisperse upconversion NaYF4:Yb3+/Er3+ nanoparticles with superior optical properties were synthesized by the oleic acid-stabilized high-temperature co-precipitation of lanthanide chlorides in octadec-1-ene as a high-boiling organic solvent. To render the particles with biocompatibility and colloidal stability in bioanalytically relevant phosphate buffered saline (PBS), they were modified by using in-house synthesized poly(ethylene glycol)-neridronate (PEG-Ner), a bisphosponate. The NaYF4:Yb3+/Er3+@PEG nanoparticles showed excellent long-term stability in PBS and/or albumin without any aggregation or morphology transformation. The in vitro cytotoxicity of the nanoparticles was evaluated using primary fibroblasts (HF) and a cell line derived from human cervical carcinoma (HeLa). The particles were subsequently modified by using Bolton–Hunter-hydroxybisphosphonate to enable radiolabeling with 125I for single-photon emission computed tomography/computed tomography (SPECT/CT) bimodal imaging to monitor the biodistribution of the nanoparticles in non-tumor mice. The bimodal upconversion 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles are prospective for near-infrared (NIR) photothermal/photodynamic and SPECT/CT cancer theranostics.
Trvalý link: http://hdl.handle.net/11104/0277584