Nuclear retinoid X receptors and adverse role of their triorganotinbased agonists in organism

0481152 - ÚIACH 2018 SK eng A - Abstrakt
Brtko, J. - Toporová, L. - Macejová, D. - Hunáková, L. - Novotný, L. - Bobálová, Janette - Dvořák, Z.
Nuclear retinoid X receptors and adverse role of their triorganotinbased agonists in organism.
Genetic toxicology and cancer prevention. Book of abstracts. Bratislava: Cancer research institute, Biomedical research center, 2017. s. 9-9. ISBN 978-80-972247-2-1.
[Genetic Toxicology and Cancer Prevention. 12.06.2017-15.06.2017, Smolenice]
Grant ostatní: AV ČR(CZ) SAV-15-01
Program: Bilaterální spolupráce
Institucionální podpora: RVO:68081715
Klíčová slova: receptor * cancer
Kód oboru RIV: CB - Analytická chemie, separace

Retinoids acting through all-trans retinoic acid nuclear receptors (RARs) are known to
inhibit carcinogenesis, suppress premalignant epithelial lesions, tumour growth and
invasion in a variety of tissues. Nuclear retinoid X receptors (RXRs) act predominantly
as heterodimers with other nuclear receptors as permissive heterodimers with
peroxisome proliferator-activated receptors, liver X receptors, farnesoid X receptor,
pregnane X receptor and constitutive androstan receptor or as non-permissive
heterodimer with vitamin D receptor, and as conditional heterodimers with retinoid
receptors (RAR), and thyroid hormone receptors. RXR - "partnef receptor
heterodimers are considered to be ligand-activated, DNA-binding, trans-acting,
transcription-modulating proteins involved in a general molecular mechanism
responsible for transcriptional responses in target genes.
Trvalý link: http://hdl.handle.net/11104/0276756