Tungsten (VI) based „molecular puzzle” photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation

0480995 - ÚMCH 2019 RIV US eng J - Článek v odborném periodiku
Lobaz, Volodymyr - Hladík, Martin - Steinhart, Miloš - Paruzel, Aleksandra - Černoch, Peter - Pánek, Jiří - Vetrík, Miroslav - Jirák, D. - Jirátová, M. - Pop-Georgievski, Ognen - Šlouf, Miroslav - Garcia-Argote, S. - Pieters, G. - Doris, E. - Hrubý, Martin
Tungsten (VI) based „molecular puzzle” photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation.
Journal of Colloid and Interface Science. Roč. 512, 15 February (2018), s. 308-317. ISSN 0021-9797. E-ISSN 1095-7103
Grant CEP: GA ČR(CZ) GA16-02870S; GA MZd(CZ) NV15-25781A; GA MŠMT(CZ) LM2015064; GA MŠMT(CZ) LO1507
Grant ostatní: OPPK(XE) CZ.2.16/3.1.00/21545
Program: OPPK
Institucionální podpora: RVO:61389013
Klíčová slova: tungsten oxide nanoparticles * doped calcium tungstate nanoparticles * adsorption of polysaccharides
Obor OECD: Physical chemistry
Impakt faktor: 6.361, rok: 2018

Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu3+ or Tb3+ nanoparticles (size range of 10–160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling. For WO3, the sorption is reversible. However, on CaWO4, stable coating is formed. CaWO4/Tb3+ coated with chemisorbed dextrin, mannan, guar gum and sodium alginate successfully underwent endocytosis with HepG2 cells and was visualized using confocal microscopy.
Trvalý link: http://hdl.handle.net/11104/0276644