Amino-functionalized nanoparticles as a platform for mTOR activity modulation in hepatocellular carcinoma Huh7 cell line

0480968 - FZÚ 2018 NL eng A - Abstrakt
Lunova, M. - Zablotskyy, Vitaliy A. - Prokhorov, Andriy - Jirsa, M. - Hof, Martin - Olžyńska, Agnieszka - Jurkiewicz, Piotr - Kubinová, Šárka - Lunov, Oleg - Dejneka, Alexandr
Amino-functionalized nanoparticles as a platform for mTOR activity modulation in hepatocellular carcinoma Huh7 cell line.
Journal of Hepatology. Elsevier. Roč. 66, č. 1 (2017), s. 645-646. ISSN 0168-8278. E-ISSN 1600-0641
Grant CEP: GA AV ČR(CZ) Fellowship J. E. Purkyně
Grant ostatní: AV ČR(CZ) Fellowship J. E. Purkyně
Program: Fellowship J. E. Purkyně
Institucionální podpora: RVO:68378271 ; RVO:61388955
Klíčová slova: nanoparticles * cancer
Obor OECD: Biophysics

Nanoparticles are gaining increase of attention as a novel class of therapeutics for cancer [1]. The liver has been recognized as a highly promising organ for nanocarrierbased targeting [2].We have previously shown that polar groups (e.g. amino or carboxyl groups) modify the cellular uptake of nanoparticles and one can use such functionalization for efficient tumour targeting [3]. Here, we show that surface functionalization and stability of the nanoparticle core can be used for selective triggering of various biological effects in hepatocellular carcinoma cells (HuH7).

Trvalý link: http://hdl.handle.net/11104/0276621