Subtractive manufacturing of customized hydroxyapatite scaffolds for bone regeneration

0480609 - ÚFM 2018 RIV GB eng J - Článek v odborném periodiku
Trunec, M. - Chlup, Zdeněk
Subtractive manufacturing of customized hydroxyapatite scaffolds for bone regeneration.
Ceramics International. Roč. 43, č. 14 (2017), s. 11265-11273. ISSN 0272-8842. E-ISSN 1873-3956
Grant CEP: GA MŠMT(CZ) LQ1601
Institucionální podpora: RVO:68081723
Klíčová slova: tissue engineering applications * in-vivo * porous hydroxyapatite * phosphate bioceramics * suspensions * ceramics * laser * optimization * osteogenesis * deposition * Milling (A) * Porosity (B) * Apatite (D) * Biopmedical properties (E) * Scaffold
Obor OECD: Ceramics
Impakt faktor: 3.057, rok: 2017

An approach to the preparation of customized hydroxyapatite scaffolds for bone regeneration based on subtractive manufacturing has been developed. The developed method is intended as a simple alternative to rapid prototyping based on additive manufacturing methods. The method for the preparation of customized scaffolds consists in computer numerical controlled (CNC) milling of porous hydroxyapatite foam. The machinable foam for customized scaffolds was prepared by direct foaming of a colloidal hydroxyapatite suspension and the foam structure was consolidated by the gelcasting method. The optimal foam after sintering reached a high porosity of 83.3% and the cellular-like structure contained spherical pores with an average diameter of 613 gm, which were connected through windows with an average diameter of 161 mu m. The compressive strength of the sintered foam reached an average value of 2 MPa. CNC milling was tested at different stages of the production cycle of the porous foam and after the reinforcing of the foam by impregnation. The best results were obtained by milling the foam presintered at 1100 degrees C. The milling process was demonstrated and scaffold examples were successfully manufactured.
Trvalý link: http://hdl.handle.net/11104/0276437