Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms

0480512 - ÚEM 2018 RIV GB eng J - Článek v odborném periodiku
Choi, H. - Tabashidze, Nana - Rössner ml., Pavel - Dostál, Miroslav - Pastorková, Anna - Kong, S.W. - Gmuender, H. - Šrám, Radim
Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.
Environmental Pollution. Roč. 231, dec (2017), s. 1134-1144. ISSN 0269-7491. E-ISSN 1873-6424
Grant CEP: GA MŠMT(CZ) 2B08005
Institucionální podpora: RVO:68378041
Klíčová slova: gene-environment interaction * polycyclic aromatic hydrocarbon * asthma
Obor OECD: Public and environmental health
Impakt faktor: 4.358, rok: 2017

We studied how the genotypic variations within the candidate genes contribute to the variability in the children's susceptibility to ambient B[a]P (benzo[a]pyrene) on doctor-diagnosed asthma.
Clinically confirmed asthmatic versus healthy control children (aged, 7 - 15 years) were enrolled from historically polluted and rural background regions in Czech Republic. Contemporaneous ambient B[a]P concentration was obtained from the routine monitoring network. The sputum DNA was genotyped for 95 genes. B[a]P interaction with SNPs (single nucleotide polymorphism) was studied by two-stage, semi-agnostic screening of 621 SNPs.The median B[a]P within the highly polluted urban center was 8-times higher than that in the background region (7.8 vs. 1.1 ng/m3) during the period of investigation. The children, who jointly experience a high B[a]P exposure (6.3 - 8.5 ng/m3) as well as susceptible genotypes in CTLA4 (rs11571316 and rs11571319), STAT4 (rs1031509), and CYP2E1 (rs2070673), respectively, are associated with a significantly greater odds of having doctor-diagnosed asthma, compared to those with neither risk factors.

Trvalý link: http://hdl.handle.net/11104/0282468