Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

0480406 - ÚPT 2018 RIV US eng J - Článek v odborném periodiku
Kovář, D. - Malá, Aneta - Mlčochová, J. - Kalina, M. - Fohlerová, Z. - Hlaváček, A. - Farka, Z. - Skládal, P. - Starčuk jr., Zenon - Jiřík, Radovan - Slabý, O. - Hubálek, J.
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging.
Journal of Nanomaterials. Roč. 2017, FEB (2017), s. 1-8, č. článku 7859289. ISSN 1687-4110. E-ISSN 1687-4129
Grant CEP: GA MŠMT(CZ) LO1212
Institucionální podpora: RVO:68081731
Klíčová slova: atomic-force microscopy * contrast agents * one-step * MRI
Obor OECD: Biophysics
Impakt faktor: 2.207, rok: 2017

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
Trvalý link: http://hdl.handle.net/11104/0276189