Počet záznamů: 1  

Microbiota and selected lactobacilli strains sustain mouse juvenile growth dynamics upon undernutrition

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    0479971 - MBÚ 2018 eng A - Abstrakt
    Schwarzer, Martin - Kassem, M. - Storelli, G. - Machuta-Gayet, I. - Šrůtková, Dagmar - Hermanová, Petra - Martino Maria Elena, M.E. - Balmand, S. - Hudcovic, Tomáš - Heddi, A. - Rieusset, J. - Kozáková, Hana - Vidal, H. - Leulier, F.
    Microbiota and selected lactobacilli strains sustain mouse juvenile growth dynamics upon undernutrition.
    Food, Microbiota and Immunity „For strong immunity – feed your microbiota well“. Praha: Czech immunological society, 2017. s. 10-10.
    [Food, Microbiota and Immunity. 07.06.2017-10.06.2017, Třešť]
    Grant CEP: GA ČR GA15-07268S
    Institucionální podpora: RVO:61388971
    Klíčová slova: Lactobacillus * juvenile growth * undernutrition
    Obor OECD: Immunology

    In most animal species, juvenile growth is characterized by an exponential gain in body weight and size. In our study we have show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet.We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.
    Trvalý link: http://hdl.handle.net/11104/0275953

     
     
Počet záznamů: 1  

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