Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

0479057 - BC 2018 RIV CH eng J - Článek v odborném periodiku
de la Fuente, J. - Antunes, S. - Bonnet, S. - Cabezas Cruz, Alejandro - Domingos, A.G. - Estrada-Peňa, A. - Johnson, N. - Kocan, K.M. - Mansfield, K. L. - Nijhof, A.M. - Papa, A. - Rudenko, Natalia - Villar, M. - Alberdi, P. - Torina, A. - Ayllón, N. - Vancová, Marie - Golovchenko, Maryna - Grubhoffer, Libor - Caracappa, S. - Fooks, A. R. - Gortazar, C. - Rego, Ryan O. M.
Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases.
Frontiers in Cellular and Infection Microbiology. Roč. 7, APR 7 (2017), č. článku 114. ISSN 2235-2988. E-ISSN 2235-2988
GRANT EU: European Commission(XE) 278976 - ANTIGONE
Institucionální podpora: RVO:60077344
Klíčová slova: tick * Anaplasma * flavivirus * Babesia * Borrelia * Microbiome * immunology * vaccine
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.520, rok: 2017

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
Trvalý link: http://hdl.handle.net/11104/0275079