DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas

0477879 - ÚMG 2018 RIV GB eng J - Článek v odborném periodiku
Benešová, Martina - Trejbalová, Kateřina - Kovářová, Denisa - Vernerová, Z. - Hron, Tomáš - Kučerová, Dana - Hejnar, Jiří
DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas.
Retrovirology. Roč. 14, č. 1 (2017), č. článku 20. E-ISSN 1742-4690
Grant CEP: GA ČR GA13-37600S; GA MZd NT14601
Institucionální podpora: RVO:68378050
Klíčová slova: Human endogenous retrovirus * ERVWE1 * Germ cell tumor * Seminoma * Promoter DNA methylation * 5-Hydroxymethylcytosine * Transcription * RNA splicing
Obor OECD: Virology
Impakt faktor: 3.417, rok: 2017

Background: Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. Previously, we have shown that the transcriptional suppression of ERVWE1 promoter is controlled epigenetically by DNA methylation and chromatin modifications. In this study, we describe the aberrant expression of syncytin-1 in biopsies of testicular germ cell tumors.
Trvalý link: http://hdl.handle.net/11104/0274098