Molecular Basis of TRPA1 Regulation in Nociceptive Neurons. A Review

0477516 - FGÚ 2018 RIV CZ eng J - Článek v odborném periodiku
Kádková, Anna - Synytsya, Viktor - Krůšek, Jan - Zímová, Lucie - Vlachová, Viktorie
Molecular Basis of TRPA1 Regulation in Nociceptive Neurons. A Review.
Physiological Research. Roč. 66, č. 3 (2017), s. 425-439. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA15-15839S; GA MZd(CZ) NV16-28784A
Institucionální podpora: RVO:67985823
Klíčová slova: transient receptor potential ankyrin 1 * bradykinin * structure- function * nociception * post-translational modifications * signaling pathways
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 1.324, rok: 2017

Transient receptor potential A1 (TRPA1) is an excitatory ion channel that functions as a cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants and endogenous products of inflammation and oxidative stress. Topical application of TRPA1 agonists produces an acute nociceptive response through peripheral release of neuropeptides, purines and other transmitters from activated sensory nerve endings. This, in turn, further regulates TRPA1 activity downstream of G-protein and phospholipase C-coupled signaling cascades. Despite the important physiological relevance of such regulation leading to nociceptor sensitization and consequent pain hypersensitivity, the specific domains through which TRPA1 undergoes post-translational modifications that affect its activation properties are yet to be determined at a molecular level. This review aims at providing an account of our current knowledge on molecular basis of regulation by neuronal inflammatory signaling pathways that converge on the TRPA1 channel protein and through modification of its specific residues influence the extent to which this channel may contribute to pain.
Trvalý link: http://hdl.handle.net/11104/0273850