Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

0477121 - ÚOCHB 2018 RIV GB eng J - Článek v odborném periodiku
Voltrová, Svatava - Muselli, Mickaël - Filgas, Josef - Matoušek, V. - Klepetářová, Blanka - Beier, Petr
Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application.
Organic & Biomolecular Chemistry. Roč. 12, č. 23 (2017), s. 4962-4965. ISSN 1477-0520. E-ISSN 1477-0539
GRANT EU: European Commission(XE) 607787 - FLUOR21
Institucionální podpora: RVO:61388963
Klíčová slova: nucleophilic tetrafluoroethylation * alkyne cycloaddition * liquid crystals
Obor OECD: Organic chemistry
Impakt faktor: 3.423, rok: 2017
http://pubs.rsc.org/en/content/articlehtml/2017/ob/c7ob01151b

Tetrafluoroethylene-containing azides are accessed in two steps (one pot) from tetrafluoroalkyl bromides by metalation and reaction with electrophilic azides. Subsequent copper(I)-catalyzed azide-alkyne cycloaddition afforded N-tetrafluoroethyl and N-tetrafluoroethylene 4-substituted 1,2,3-triazoles. In addition, the protocol for the synthesis of 4,5-disubstituted 1,2,3-triazoles is presented.
Trvalý link: http://hdl.handle.net/11104/0273501