Počet záznamů: 1
Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex
- 1.0476269 - BFÚ 2018 RIV GB eng J - Článek v odborném periodiku
Hrabina, O. - Kašpárková, J. - Suchánková, Tereza - Novohradský, Vojtěch - Guo, Z. - Brabec, Viktor
Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex.
Metallomics. Roč. 9, č. 5 (2017), s. 494-500. ISSN 1756-5901. E-ISSN 1756-591X
Institucionální podpora: RVO:68081707
Klíčová slova: cisplatin-modified dna * nucleotide excision-repair * hmg domain proteins
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.069, rok: 2017
The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3'-3' direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.
Trvalý link: http://hdl.handle.net/11104/0272811
Počet záznamů: 1