Novel Biomaterials in Regenerative Medicine

0476182 - ÚEM 2018 RIV CZ eng M - Část monografie knihy
Míčková, Andrea - Buzgo, M. - Amler, Evžen
Coaxial Nanofibers for Drug Delivery of Bioactive Molecules.
Novel Biomaterials in Regenerative Medicine. 2016: Epika, 2016 - (Caraglia, M.; Desiderio, V.), s. 246-251. ISBN 978-80-88113-69-0
Grant CEP: GA MŠMT(CZ) LO1508
Institucionální podpora: RVO:68378041
Klíčová slova: coaxial nanofibers * drug delivery * electrospinning techniques
Obor OECD: Nano-materials (production and properties)

The developmet of nanofibers has greatly enhanced the scope for preparation of scaffolds that mimic the structure and biological function of extracellular matrix (ECM). Nanofibers formed by electrospinning techniques offer distinct advantages of biocompatibility and biodegradability, versatility of chemistry and mechanical properties. Small diameter that closely matches the sice scale of the ECM, the high surface area-to-volume ratio of nanofibers, optimal pore size and porosity as high as 90%, makes them suitable for cell attachment, proliferation, differentiation and drug loading. Such unique properties of nanofibers scaffolds determine their use in tissue engineering and regenerative medicine (Filova et al.2013, Rampichova et al.2013).
Trvalý link: http://hdl.handle.net/11104/0272709