New adenoviruses from new primate hosts - growing diversity reveals taxonomic weak points

0475020 - BC 2018 RIV US eng J - Článek v odborném periodiku
Dadáková, E. - Chrudimský, Tomáš - Brožová, K. - Modrý, David - Celer, V. - Hrazdilová, K.
New adenoviruses from new primate hosts - growing diversity reveals taxonomic weak points.
Molecular Phylogenetics and Evolution. Roč. 107, February (2017), s. 305-307. ISSN 1055-7903. E-ISSN 1095-9513
Institucionální podpora: RVO:60077344
Klíčová slova: adenovirus * primate * phylogeny * taxonomy
Obor OECD: Microbiology
Impakt faktor: 4.412, rok: 2017

The knowledge of the closest human relatives of human adenoviruses (AdVs) such as adenoviruses found in nonhuman primates is still limited, despite the growing importance of adenoviruses in vaccine development, gene and cancer therapy. We examined 153 stool samples of 17 non-human primate species and detected adenoviral DNA sequences of DNA polymerase (DPOL) gene in 54 samples (35%), originating from 12 out of 17 primate species. We further sequenced 15 hexon gene fragments and based on the phylogenetic analysis we propose two new provisional species SAdV-H and SAdV-I. Our study shows extensive diversity of adenoviral strains forming separate clades often from closely related host species from old world monkeys suggesting the existence of new species of AdVs and shows the necessity for clear ICTV guidelines for final establishment of so far provisional AdV species.
Trvalý link: http://hdl.handle.net/11104/0277678