Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces

0474915 - ÚMCH 2018 RIV GB eng J - Článek v odborném periodiku
Mázl Chánová, Eliška - Pop-Georgievski, Ognen - Kumorek, Marta M. - Janoušková, Olga - Machová, Luďka - Kubies, Dana - Rypáček, František
Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces.
Biomaterials Science. Roč. 5, č. 6 (2017), s. 1130-1143. ISSN 2047-4830. E-ISSN 2047-4849
Grant CEP: GA ČR(CZ) GJ15-09368Y; GA MZd(CZ) NV16-28254A; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:61389013
Klíčová slova: polymer brush * poly(ethylene oxide) * polylactide
Obor OECD: Polymer science
Impakt faktor: 5.831, rok: 2017

In this study we investigate the formation of protein-resistant polymer surfaces, such as aliphatic polyesters, through the deposition of self-assemblies of amphiphilic poly(L-lactide)-b-poly(ethylene oxide), PLLA-b-PEO, copolymers as stable nanoparticles with a kinetically frozen PLLA core on model PLLA surfaces. The length of the PEO chains in the corona was tuned to achieve polymer brushes capable of preventing protein adsorption on PLA-based biomaterials. The spectroscopic ellipsometry, IR and XPS analysis, contact angle goniometry, and AFM proved that the PEO chains adopted a brush structure and were preferably exposed on the surface. The low-fouling properties of the physisorbed PLLA-b-PEO layers approached the ones of reactive grafting methods, as shown by surface plasmon resonance spectroscopy. The anti-fouling properties of the prepared PEO brushes provided sufficient interface to prevent cell adhesion as proved in vitro. Thus, the developed surface coating with PLLA-b-PEO colloids can provide an anti-fouling background for the creation of nanopatterned biofunctionalized surfaces in biomedical applications.
Trvalý link: http://hdl.handle.net/11104/0272226