Mitochondrial Complex II: At the Crossroads

0474448 - BTÚ 2018 RIV GB eng J - Článek v odborném periodiku
Bezawork-Geleta, A. - Rohlena, Jakub - Dong, L. - Pacak, K. - Neužil, Jiří
Mitochondrial Complex II: At the Crossroads.
Trends in Biochemical Sciences. Roč. 42, č. 4 (2017), s. 312-325. ISSN 0968-0004. E-ISSN 1362-4326
Grant CEP: GA ČR GA15-02203S; GA ČR(CZ) GA16-12719S; GA ČR GA17-20904S; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: GASTROINTESTINAL STROMAL TUMORS * SUCCINATE-DEHYDROGENASE ACTIVITY * ALPHA-TOCOPHERYL SUCCINATE
Obor OECD: Cell biology
Impakt faktor: 15.678, rok: 2017

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This review also covers the recent discovery of the role of SDH in inflammation-linked pathologies. Conceivably, SDH is a potential target for several hard-to-treat conditions, including cancer, that remains to be fully exploited.
Trvalý link: http://hdl.handle.net/11104/0271499