Lost in translation: Defects in transfer RNA modifications and neurological disorders

0474108 - BC 2018 RIV CH eng J - Článek v odborném periodiku
Bednářová, Andrea - Hanna, M. - Durham, I. - Van Cleave, T. - England, A. - Chaudhuri, A. - Krishnan, N.
Lost in translation: Defects in transfer RNA modifications and neurological disorders.
Frontiers in Molecular Neuroscience. Roč. 10, MAY 09 (2017), č. článku 135. ISSN 1662-5099. E-ISSN 1662-5099
Grant ostatní: AV ČR(CZ) L200961701
Institucionální podpora: RVO:60077344
Klíčová slova: transfer RNA modifications * modified nucleosides * neurological disease
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 3.902, rok: 2017
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422465/

Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their functionality they undergo extensive post-transcriptional modifications and, as such, are subject to regulation at multiple levels including transcription, transcript processing, localization and ribonucleoside base modification. Post-transcriptional enzyme-catalyzed modification of tRNA occurs at a number of base and sugar positions and influences specific anticodon - codon interactions and regulates translation, its efficiency and fidelity. This phenomenon of nucleoside modification is most remarkable and results in a rich structural diversity of tRNA of which over 100 modified nucleosides have been characterized. Most often these hypermodified nucleosides are found in the wobble position of tRNAs, where they play a direct role in codon recognition as well as in maintaining translational efficiency and fidelity, etc. Several recent studies have pointed to a link between defects in tRNA modifications and human diseases including neurological disorders. Therefore, defects in tRNA modifications in humans need intensive characterization at the enzymatic and mechanistic level in order to pave the way to understand how lack of such modifications are associated with neurological disorders with the ultimate goal of gaining insights into therapeutic interventions.
Trvalý link: http://hdl.handle.net/11104/0271971